The Effect of Anabolic Androgenic Steroids on Calcitonin Gene-related Peptide (cgrp) Levels in the Rat Brain

نویسندگان

  • Mathias Hallberg
  • Kristina Magnusson
چکیده

Objective: The aim of the present study was to determine whether anabolic androgenic steroids (AAS) have an effect on the levels of calcitonin gene-related peptide (CGRP) in the rat brain, using nandrolone decanoate as a prototype steroid. Method: Male Sprague-Dawley rats received daily intramuscular injections of nandrolone decanoate (15 mg/kg) for 14 days. The effect of AAS on CGRP immunoreactivity (CGRP-ir) in various regions of the rat brain was investigated using radioimmunoassay. Results: The AAS administration caused a significant increase in CGRP-ir in the nucleus accumbens and the amygdala. After three weeks of recovery, a high level of CGRP-ir still remained in the nucleus accumbens. On the contrary, in the anterior pituitary the CGRP-ir levels became significantly lower after administration of nandrolone decanoate. Conclusion: The observed alterations of the CGRP-ir levels could have an impact on biochemical events that are associated with the adverse behaviors and physical effects observed in connection to AAS abuse. KEYWORDS Anabolic androgenic steroids, nandrolone decanoate, calcitonin gene-related peptide, rat brain, radioimmunoassay. Hallberg et al.

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تاریخ انتشار 2005